{"id":4439,"date":"2018-11-10T12:47:33","date_gmt":"2018-11-10T03:47:33","guid":{"rendered":"https:\/\/watanabe-biyohifuka.com\/?p=4439"},"modified":"2018-11-10T12:47:33","modified_gmt":"2018-11-10T03:47:33","slug":"%e3%80%8c%e7%82%8e%e7%97%87%e3%81%ae%e3%83%ab%e3%83%bc%e3%83%97%e3%80%8d%e3%82%92%e3%81%82%e3%82%89%e3%82%86%e3%82%8b%e8%a7%92%e5%ba%a6%e3%81%8b%e3%82%89%e6%96%ad%e3%81%a1%e5%88%87%e3%82%8b%e3%81%93","status":"publish","type":"post","link":"https:\/\/tonarino.clinic\/blog\/0729934676\/2018\/11\/%e3%80%8c%e7%82%8e%e7%97%87%e3%81%ae%e3%83%ab%e3%83%bc%e3%83%97%e3%80%8d%e3%82%92%e3%81%82%e3%82%89%e3%82%86%e3%82%8b%e8%a7%92%e5%ba%a6%e3%81%8b%e3%82%89%e6%96%ad%e3%81%a1%e5%88%87%e3%82%8b%e3%81%93.html","title":{"rendered":"\u300c\u708e\u75c7\u306e\u30eb\u30fc\u30d7\u300d\u3092\u3042\u3089\u3086\u308b\u89d2\u5ea6\u304b\u3089\u65ad\u3061\u5207\u308b\u3053\u3068"},"content":{"rendered":"

\t\t\t\t\u300c\u795e\u7d4c\u6d3b\u6027\u5316\u306b\u3088\u308b\u708e\u75c7\u53cd\u5fdc\u306e\u5236\u5fa1\u300d\u3068\u3044\u3046\u5317\u5927\u306e\u3000\u6751\u4e0a\u6b63\u6643\u5148\u751f\u306e\u8ad6\u6587\u3092\u8aad\u307f\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u3000\u3000\u305d\u306e\u4e2d\u306b\u306f<\/span><\/span><\/span><\/p>\n

\u300c\u708e\u75c7\u306e\u5897\u5e45\u56de\u8def\u306e\u767a\u898b\u300d\u3000\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u308a\u3001<\/span><\/span><\/p>\n

\u300c\u30de\u30a6\u30b9\u306b IL-17 \u3092\u5f37\u5236\u767a\u73fe\u3055\u305b\u308b\u3068\u904e\u5270\u306a IL-6 \u304c\u7523\u751f\u3055\u308c\uff0cF759 \u30de\u30a6\u30b9\u306b\u3066\u540c\u69d8\u306e\u5b9f\u9a13\u3092\u884c\u3046\u3068\u3055\u3089\u306b 10\u500d\u4ee5\u4e0a\u306e IL-6 \u304c\u3000\u7523\u751f\u3055\u308c\u305f\u3002\u8a66\u9a13\u7ba1\u5185\u306e\u89e3\u6790\u304b\u3089\u3082\uff0cIL- 17 \u3068 IL-6 \u306e\u540c\u6642\u523a\u6fc0\u306b\u3088\u3063\u3066\u76f8\u4e57\u7684\u306b IL-6 \u304c\u767a\u73fe\u3057\u305f\u3002<\/span>
\n\u79c1\u305f\u3061\u306f\u3053\u306e\u6a5f\u69cb\u3092 IL-6 \u7523\u751f\u306e\u5897\u5e45\u56de\u8def\u3068\u540d\u4ed8\u3051\u3066\u7814\u7a76\u3092\u884c\u3063\u3066 F759 \u95a2\u7bc0\u708e\uff0c<\/span>\u591a\u767a\u6027\u786c\u5316\u75c7\u30e2\u30c7\u30eb (EAE)\u3067\u306e\u305d\u308c\u3089\u306e\u767a\u75c7\u3000\u3000\u306b\u3000\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/span>
\n \u3055\u3089\u306b\uff0c\u672c\u6a5f\u69cb\u306e\u89e3\u6790\u3092\u7d9a\u3051\u3066\u3044\u304f\u3068\u975e\u514d\u75ab\u7cfb\u7d30\u80de\u306b\u3066 NFkB \u3068 STAT3 \u304c\u540c\u6642\u306b\u6d3b\u6027\u5316\u3059\u308b\u3068\u00a0NFkB \u904e\u5270\u6d3b\u6027\u5316\u304c\u8a98\u5c0e\u3055\u308c\uff0c\u305d\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u7fa4\u304c\u904e\u5270\u767a\u73fe\u3057\u305f\u3002\u3000IL-6 \u306f\u305d\u306e\u30dd\u30b8\u30c6\u30a3\u30d6\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u30eb\u30fc\u30d7\u306b\u3066\u00a0\u3001STAT3 \u6d3b\u6027\u5316\u3092\u7dad\u6301\u3057\uff0c\u5b9f\u969b\u306e\u6a5f\u80fd\u5206\u5b50\u306f NFkB \u306e\u6a19\u7684\u907a\u4f1d\u5b50\u3067\u3042\u308b\u30b1\u30e2\u30ab\u30a4\u30f3\uff0c\u5897\u6b96\u56e0\u5b50\u306a\u3069\u3067\u3042\u3063\u305f\u3002\u3000\u3053\u308c\u3089\u304c\u5c40\u6240\u3067\u904e\u5270\u3068\u306a\u308c\u3070\uff0c\u305d\u3053\u3078\u514d\u75ab\u7d30\u80de\u306e\u6d78\u6f64\u304c\u751f\u3058\u6052\u5e38\u6027\u304c\u7834\u7dbb\u3059\u308b\u3002\u300d<\/span><\/p>\n

\u3000\u79c1\u305f\u3061\u306f\u3053\u308c\u3089\u306e\u73fe\u8c61\u3092\u300c\u708e\u75c7\u300d\u3068 \u547c\u3093\u3067\u3044\u308b\u3053\u3068\u304c\u5224\u3063\u305f\u3002<\/span><\/p>\n

\u300c\u708e\u75c7\u306e\u5897\u5e45\u56de\u8def\uff0c\u708e\u75c7\u56de\u8def (Inflammation Amplification Loop\uff0cInflammation Amp)\u300d\u3068\u3044\u3046\u3079\u304d\u3082\u306e\u3067\u3042\u3063\u305f\u3002<\/span>
\n \u75be\u60a3\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u5b9f\u9a13\u304b\u3089\uff0c\u708e\u75c7\u56de\u8def\u306f\uff0c\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff0c\u591a\u767a\u6027\u786c\u5316\u75c7\u306a\u3069\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u79fb\u690d\u306e\u6162\u6027\u62d2\u7d76\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span><\/p>\n

\u00a0<\/p>\n

\u3000\u7c21\u5358\u306b\u8a00\u3046\u3068\u3001\u30b9\u30c8\u30ec\u30b9\u3001\u8178\u5185\u306e\u74b0\u5883\u3001\u4f53\u306e\u6b6a\u307f\u306a\u3069\u304b\u3089\u3001\u5ef6\u3005\u3068\u708e\u75c7\u306e\u60aa\u5faa\u74b0\u304c\u7d9a\u3044\u3066\u3044\u3063\u3066\u3057\u307e\u3046\u30fb\u30fb\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u3053\u308c\u306f\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3001\u5c0b\u5e38\u6027\u4e7e\u766c\u3001\u6e7f\u75b9\u3001\u9152\u3055\u30fb\u30fb\u3082\u3046\u3001\u3069\u3093\u306a\u76ae\u819a\u75c5\u306b\u3082\u3042\u3066\u306f\u307e\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/span><\/span><\/p>\n

\u3000\u3053\u308c\u3089\u306e\u300c\u708e\u75c7\u306e\u30eb\u30fc\u30d7\u300d\u3092\u3042\u3089\u3086\u308b\u89d2\u5ea6\u304b\u3089\u65ad\u3061\u5207\u308b\u3053\u3068\u304c\u300c\u672c\u6cbb\u300d\u3068\u3044\u3048\u308b<\/span>\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\u5f53\u9662\u3067\u306e\u6f22\u65b9\u85ac\u3001\u98df\u4e8b\u6307\u5c0e\u3001\u305d\u306e\u4ed6\u306f\u3000\u3053\u3053\u3092\u76ee\u6307\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/span><\/p>\n

\"\"<\/a><\/p>\n

\u00a0\t\t<\/p>\n","protected":false},"excerpt":{"rendered":"

\u300c\u795e\u7d4c\u6d3b\u6027\u5316\u306b\u3088\u308b\u708e\u75c7\u53cd\u5fdc\u306e\u5236\u5fa1\u300d\u3068\u3044\u3046\u5317\u5927\u306e\u3000\u6751\u4e0a\u6b63\u6643\u5148\u751f\u306e\u8ad6\u6587\u3092\u8aad\u307f\u307e\u3057\u305f\u3002 \u3000\u3000\u305d\u306e\u4e2d\u306b\u306f \u300c\u708e\u75c7\u306e\u5897\u5e45\u56de\u8def\u306e\u767a\u898b\u300d\u3000\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u308a\u3001 \u300c\u30de\u30a6\u30b9\u306b IL-17 \u3092\u5f37\u5236\u767a\u73fe\u3055\u305b\u308b\u3068\u904e\u5270\u306a IL-6 \u304c\u7523\u751f\u3055\u308c\uff0cF7 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,25],"tags":[],"class_list":["post-4439","post","type-post","status-publish","format-standard","hentry","category-6","category-blog"],"_links":{"self":[{"href":"https:\/\/tonarino.clinic\/blog\/0729934676\/wp-json\/wp\/v2\/posts\/4439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tonarino.clinic\/blog\/0729934676\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tonarino.clinic\/blog\/0729934676\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tonarino.clinic\/blog\/0729934676\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/tonarino.clinic\/blog\/0729934676\/wp-json\/wp\/v2\/comments?post=4439"}],"version-history":[{"count":0,"href":"https:\/\/tonarino.clinic\/blog\/0729934676\/wp-json\/wp\/v2\/posts\/4439\/revisions"}],"wp:attachment":[{"href":"https:\/\/tonarino.clinic\/blog\/0729934676\/wp-json\/wp\/v2\/media?parent=4439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tonarino.clinic\/blog\/0729934676\/wp-json\/wp\/v2\/categories?post=4439"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tonarino.clinic\/blog\/0729934676\/wp-json\/wp\/v2\/tags?post=4439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}